There was a large police cordon in place on Idle Road after a collision near The Swing Gate pub.
West Yorkshire Police say the incident occurred just before 3am in the early hours of this morning.
Yorkshire Ambulance Service added that one person was taken to hospital.
Both cars were heavily damaged and there was debris strewn across the road.
Cars were being turned away from the scene for a number of hours until the road was reopened at around 10.15am.
A spokesperson for the force: “At 2.54am today, police received a report of two cars having been involved in a collision in Idle Road, Bradford.
“Officers attended and found a Mercedes and a Golf which appeared to have collision damage close to The Swing Gate pub.
“Enquiries are ongoing to locate those involved and an earlier road closure has now been lifted following the recovery of both vehicles.
“Anyone with information is asked to contact police on 101, or by using the livechat facility on the West Yorkshire Police website, quoting log 129 of October 25.”
A spokesperson for the Yorkshire Ambulance Service said: “We received an emergency call at 3.34am on Friday morning to report a collision involving two vehicles on Idle Road, Bradford.
“An ambulance was dispatched to the scene and one patient was conveyed to Bradford Royal Infirmary.”
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