Like Murray, Nadal is also playing in his final Olympics and it is still unclear how long his career will continue.
The 38-year-old Spaniard has been struggling with injury over the past couple of years but is fit enough to play in both the singles and doubles in Paris.
Nadal, who has won a record 14 men’s singles titles at Roland Garros, starts against Hungary’s Marton Fucsovics – with the carrot of potentially continuing his enduring rivalry against Serbia’s Djokovic.
Top seed Djokovic, 37, plays Australia’s Matt Ebden in his opening match.
British number one Jack Draper faces 2016 bronze medallist Nishikori, with Cameron Norrie against Tallon Griekspoor of the Netherlands knowing he could face French Open and Wimbledon champion Carlos Alcaraz in the second round.
Evans plays Tunisia’s Moez Echargui, while Katie Boulter – Britain’s sole representative in the women’s singles – starts against Slovakia’s Anna Karolina Schmiedlova.
Boulter will team up with Heather Watson in the women’s doubles. They have been drawn against Germany’s Angelique Kerber – the 2016 silver medallist in the singles, who has announced she will retire after these Games – and Laura Siegemund.
Joe Salisbury and Neal Skupski, who are seeded fifth in the men’s doubles, face Czech pair Tomas Machac and Adam Pavlasek.
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