Both teams secured victory to open the second stage of the tournament, the Proteas getting the better of the USA by 18 runs and England beating West Indies by eight wickets.
Those results mean that, whatever happens in Saint Lucia, these two are the favourites to qualify from the short Super 8s stage.
But the honour of topping the group could be key to the semi-final layout – although there are certainly going to be no easy draws at the penultimate stage.
England fans can also breathe a sigh of relief that today’s game does not take place overnight, having endured a 1.30am start last time out.
How to watch England vs South Africa
TV channel: In the UK, the T20 World Cup game will be broadcast on Sky Sports Cricket and Main Event channels. Coverage starts at 3pm with the game getting underway at 3.30pm BST.
Live stream: Subscribers can watch live online via the Sky Go app.