After Liverpool were held to a 2-2 draw at home by Fulham on Saturday, the Blues will look to take full advantage and continue their good form under Enzo Maresca.
Arsenal also dropped points on Saturday when they drew 0-0 with Everton and victory against Brentford would also see Chelsea move four points clear of the Gunners.
Maresca continues to insist his side are not title challengers but another win would leave them in a great position going into the busy festive period.
But fans in the UK will not be able to watch the game – despite the unusual kick-off time of Sunday night at 7pm GMT.
Why isn’t Chelsea vs Brentford on TV in UK today?
As such, despite moving date and time because of Chelsea played away in Kazakhstan in the Conference League on Thursday night, it cannot be shown in the UK.
How to follow Chelsea vs Brentford
Free highlights: BBC One’s Match of the Day 2, however, will broadcast highlights when it airs at 10.30pm on Sunday.