Key to France’s lack of goals has been the disappointing form of forwards Mbappe and Antoine Griezmann.
Mbappe has struggled since having to wear a mask after breaking his nose during France’s opening 1-0 win against Austria.
The striker, who this summer joined Real Madrid from Paris St-Germain, scored eight of France’s 16 goals at the World Cup in Qatar two years ago as they reached the final, where they were beaten by Argentina.
Despite just scoring one goal so far in Germany, France captain Mbappe is likely to start against Spain.
“We are convinced Kylian is in the right headspace, as are all of our players,” Deschamps added.
“He had an issue with his back, took a blow to the nose – it could have been the end of the road for him but he’s still here.
“His field of vision is changed and it was a huge shock to him but I’m convinced he will do everything he can [against Spain].”
Atletico Madrid striker Griezmann has yet to score, but team-mate Adrien Rabiot says all the players are right behind him.
“I think everyone is surprised because we know what Antoine is capable of,” Rabiot said.
“We saw what he pulled out of the bag at the World Cup, where he was at the peak of his powers as a player.
“I don’t know the reason. We have high expectations when it comes to Antoine and we expect a lot because he’s capable.
“If someone’s having a rough patch then we’re here to support them, but obviously it’d be better if we had the Kylian and the Antoine [we know] playing here at the Euros.”
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